Wastewater issues include limitations and standards for four pharmaceutical manufacturing subcategories: A (Fermentation), B (Extraction), C (Chemical Synthesis), and D (Mixing, Compounding, and Formulating). EPA has published final direct and indirect discharge standards for the four subcategories, as well as final MACT standards under the Clean Air Act. The MACT standards final rule controls emissions of hazardous air pollutants. There have been and will continue to be new and modified regulatory and policy documents issued by EPA in both the wastewater and air segments.